Acyclovir cream 5% is used to treat cold sores (caused by herpes zoster virus), first outbreaks of genital herpes (forming around the genitalia or the rectum) and to treat certain types of sores caused by the herpes simplex virus in people with weak immune systems. It belongs to a class of medicines called synthetic nucleoside analogues and it works by stopping the spread of herpes virus in the body.

Usage instructions

It should be applied on the affected area five times a day or as directed by the doctor. Acyclovir cream may be applied at any time during a cold sore outbreak, but it works best when it is applied at the very beginning of a cold sore outbreak when there is tingling, redness, itching, or a bump but the cold sore has not yet formed.


For external use only. Do not apply to broken skin. Do not let acyclovir cream get into your eyes, or inside your mouth or nose, and do not swallow the medication.


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