Levofloxacin is an antibiotic that that may be used to treat different types of bacterial infections. Levofloxacin may also be used to treat people who have been exposed to anthrax or certain types of plague.
Levofloxacin Tablets is indicated in adults for the treatment of the following infections.
• Acute bacterial sinusitis
• Acute exacerbation of chronic obstructive pulmonary disease including bronchitisUncomplicated cystitis.
• Community-acquired pneumonia
• Complicated skin and soft tissue infections
For the above-mentioned infections Levofloxacin Tablets should be used only when it is considered inappropriate to use antibacterial agents that are commonly recommended for the initial treatment of these infections.
• Acute pyelonephritis and complicated urinary tract infections Chronic bacterial prostatitis.
• Inhalation Anthrax: postexposure prophylaxis and curative treatment.
Levofloxacin Tablets may also be used to complete a course of therapy in patients who have shown improvement during initial treatment with intravenous levofloxacin.
500 mg PO/IV once daily for 7-14 days or 750 mg PO/IV once daily for 5 days
750 mg PO/IV once daily for 7-14 days
500 mg PO/IV once daily for 10-14 days or 750 mg PO/IV once daily for 5 days
Limitations-of-use: Reserve fluoroquinolones for patients who do not have other available treatment options for acute sinusitis
500 mg PO/IV once daily for ≥7 days
Limitations-of-use: Reserve fluoroquinolones for patients who do not have other available treatment options for acute bacterial exacerbation of chronic bronchitis
500 mg PO once daily for 60 days, beginning as soon as possible after exposure
Uncomplicated: 500 mg PO/IV once daily for 7-10 days
Complicated: 750 mg PO/IV once daily for 7-14 days
500 mg PO/IV once daily for 28 days
250 mg PO/IV once daily for 10 days or 750 mg PO/IV once daily for 5 days
250 mg PO/IV once daily for 3 days
Limitations-of-use: Reserve fluoroquinolones for patients who do not have other available treatment options for uncomplicated urinary tract infections
Indicated for treatment and prophylaxis of plague, including pneumonic and septicemic plague, caused by Yersinia pestis in adults and pediatric patients, aged 6 months or older
500 mg PO/IV once daily for 10-14 days
100 mg PO q8hr for 4 weeks
500 mg PO qDay for 10 days
Cardiac: Cardiac arrest, palpitation, ventricular tachycardia, arrhythmia
Nervous system: Tremor, convulsions, paresthesia, vertigo, hypertonia, hyperkinesias, abnormal gait, somnolence, syncope
Metabolic: Hypoglycemia, hyperglycemia, hyperkalemia
Blood/lymphatic system: Anemia, thrombocytopenia, granulocytopenia
Musculoskeletal/connective tissue: Arthralgia, tendonitis, myalgia, skeletal pain
Gastrointestinal (GI): Gastritis, stomatitis, pancreatitis, esophagitis, gastroenteritis, glossitis, pseudomembranous/C difficile colitis
Hepatobiliary: Abnormal hepatic function, increased hepatic enzymes, increased alkaline phosphatase
Psychiatric: Anxiety, agitation, confusion, depression, hallucinations, nightmares, sleep disorder, anorexia, abnormal dreaming
Other: Immune hypersensitivity reaction, acute renal failure, urticaria, phlebitis, epistaxis.