SUNITIX (SUNITINIB) 50MG CAPSULES 28`S

KSh99,330.00

Sunitinib) is used in the treatment of advanced kidney cancer, gastrointestinal stromal tumours (GISTs), and pancreatic neuroendocrine tumours. Sunitinib is a protein kinase inhibitor that works by blocking this enzyme to prevent the cancer growing.

SKU: DP9219 Category:

INDICATIONS.

Gastrointestinal stromal tumour (GIST)

Sutent is indicated for the treatment of unresectable and/or metastatic malignant gastrointestinal stromal tumour (GIST) in adults after failure of imatinib treatment due to resistance or intolerance.

Metastatic renal cell carcinoma (MRCC)

Sutent is indicated for the treatment of advanced/metastatic renal cell carcinoma (MRCC) in adults.

Pancreatic neuroendocrine tumours (pNET)

Sutent is indicated for the treatment of unresectable or metastatic, well-differentiated pancreatic neuroendocrine tumours (pNET) with disease progression in adults.

DOSAGE.

For GIST and MRCC, the recommended dose of Sutent is 50 mg taken orally once daily, for 4 consecutive weeks, followed by a 2-week rest period (Schedule 4/2) to comprise a complete cycle of 6 weeks.

For pNET, the recommended dose of Sutent is 37.5 mg taken orally once daily without a scheduled rest period.

For GIST and MRCC, dose modifications in 12.5 mg steps may be applied based on individual safety and tolerability. Daily dose should not exceed 75 mg nor be decreased below 25 mg.

For pNET, dose modification in 12.5 mg steps may be applied based on individual safety and tolerability. The maximum dose administered in the Phase 3 pNET study was 50 mg daily.

Dose interruptions may be required based on individual safety and tolerability.

ADVERSE EFFECTS.

Viral infections

Respiratory infections

Abscess

Fungal infections

Urinary tract infection

Skin infections

Sepsis

Necrotising fasciitis

Bacterial infections

Posterior reversible encephalopathy syndrome

Cardiac failure congestive

Myocardial infarction

Cardiac failure

Cardiomyopathy

Pericardial effusion

Electrocardiogram QT prolonged

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