SULPHADIAZINE 500MG TABLETS 100s

KSh3,460.00

SKU: DP8756 Category:

INDICATIONS.

Sulfadiazine is a short-acting sulphonamide with bacteriostatic activity against a broad spectrum of organisms.

Gram-positive – particularly group A Streptococci and some strains of Streptococcus pneumoniae, Bacillus ant hracis, Nocardia (especially N.asteroides) and, to a lesser extent, Staphylococci and Clostridium perfringens.

Gram-negative – Haemophilus influenzae and H.ducreyi are often sensitive, sensitivity varies among the enterobacteriae-Escherichia coli, Klebsiella, proteus, Salmonella and Serratia and Vibrio cholerae are sometimes sensitive. Other organisms reported to be sensitive include, Actinomyces spP., Brucella, Calymmatobacterium granulomatis, Legionella, Yersinia pestis, Chlamydia, Pseudomonas pseudomallei.

DOSAGE.

Adults and elderly

The initial dose is usually 2-4 grams followed by a maintenance dose of up to 4 grams daily in divided doses for a maximum of seven days.

Dosage reduction may be necessary in renal impairment.

 

Children

Initially 75mg/kg, followed by a maintenance dose of 150mg/kg daily in divided doses. Maximum of 6 grams daily.

Sulphonamides should not be used for initial treatment of meningococcal meningitis although oral Sulfadiazine may be substituted for parenteral penicillin once susceptibility to sulphonamides has been established.

ADVERSE EFFECTS.

Diarrhea

Headache

Reversible oligospermia

Anorexia

Gastric distress

Nausea

Photosensitivity

Vomiting

Allergic reactions-rash

Aplastic anemia

Dizziness

Hypersensitivity

Itching

Thyroid fuction disturbance

Franulocytopenia

Thrombocytopenia

Frequency Not Defined

Lyell’s syndrome

Sstevens Johnson syndrome

Rash

Fever

Granulocytopenia

Hemolytic anemia

Leukopenia

Hepatitis

Jaundice

Hematuria

Acute nephropathy

Intestinal nephritis

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