SPORANOX ITRACONAZOLE 100MG CAPSULES 15`S

KSh5,500.00

SKU: DP8311 Category:

INDICATIONS.

Itraconazole is used to treat serious fungal or yeast infections.

Itraconazole oral solution is only used to treat oropharyngeal or esophageal candidiasis (thrush, oral thrush).

Itraconazole capsule is used to treat fungal infections, such as aspergillosis (fungal infection in the lungs), blastomycosis (Gilchrist’s disease), or histoplasmosis (Darling’s disease).

Itraconazole capsule is also used to treat onychomycosis (fungal infection in the fingernails or toenails).

Itraconazole tablet is only used to treat onychomycosis of the toenails. This medicine works by killing the fungus or yeast and preventing its growth.

DOSAGE.

Blastomycosis

Indicated for treatment of blastomycosis, including pulmonary and extrapulmonary infections in immunocompromised and nonimmunocompromised adults

Sporanox
  • 200 mg PO qDay
  • If no improvement, or evidence of progressive fungal disease, increase dose in 100-mg increments to a maximum of 400 mg/day
  • Divide doses >200 mg/day into 2 doses
Tolsura
  • 130 mg PO qDay
  • If no improvement, or evidence of progressive fungal disease, increase dose in 65 mg increments to a maximum of 260 mg/day (130 mg BID)
  • Divide doses >130 mg/day into 2 doses
Aspergillosis

Indicated for treatment of pulmonary and extrapulmonary aspergillosis in immunocompromised and nonimmunocompromised adults who are intolerant of or refractory to amphotericin B therapy

Onychomycosis

Indicated for treatment of onychomycosis of the toenail due to Trichophyton rubrum or T. mentagrophytes in nonimmunocompromised patients

Fingernails (Sporanox only): 2 treatment pulses, each consisting of 200 mg q12hr for 1 week; pulses are separated by a 3-week period without Sporanox

Toenails, with or without fingernail involvement (Sporanox, Onmel): 200 mg/day PO for 12 weeks

Candidiasis

Indicated for treatment of oropharyngeal and esophageal candidiasis

Esophageal candidiasis

  • 100 mg (10 mL) PO qDay for a minimum of 3 weeks; continue treatment for 2 weeks following resolution of symptoms
  • Doses ≤200 mg/day (20 mL) may be used based on medical judgment of the patient’s response to therapy
Oropharyngeal candidiasis
  • Oral solution only: 200 mg (20 mL) PO qDay for 1-2 weeks; signs and symptoms of oropharyngeal candidiasis generally resolve within several days
  • Unresponsive/refractory to fluconazole: 100 mg (10 mL) PO BID
  • Clinical response will be seen in 2-4 weeks
  • May be expected to relapse shortly after discontinuing therapy
  • Limited data on safety of long-term use (>6 months) of oral solution are available at this time
Otomycosis (Orphan)

Suspension: Topical treatment of fungal otitis externa (otomycosis)

ADVERSE EFFECTS.

Headache

Rhinitis

Upper respiratory tract infection

Sinusitis, injury

Diarrhea

Dyspepsia

Flatulence

Abdominal pain

Dizziness

Rash

Elevated liver enzymes

Gastrointestinal disorders

Rash

Cystitis

Urinary tract infection

Liver function abnormality

Myalgia

Nausea

Hypertension

Appetite increased

Constipation

Gastritis, gastroenteritis

Pharyngitis

Abnormal dreaming

Orthostatic hypertension

Headache

Malaise

Myalgia

Vasculitis

Vertigo

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