i) Use of drugs which can induce potassium depletion eg. frusemide, thiazide diuretics, corticosteroids, carbenoxolone and cardiac glycosides, especially in combination with diuretics
ii) Potassium loss resulting from severe diarrhoea, vomiting or fistulas;
iii) Acid-base disturbances e.g. alkalosis, renal tubular acidosis, states in which there is aldosterone excess, Cushing syndrome;
iv) Decreased intake of potassium e.g. malnutrition, alcoholism, some elderly patients with deficient diets;
v) Since span k Effervescent Tablets contain Cl- they may be used in the treatment of hypokalaemia associated with hypochloraemic alkalosis.