CYTOTEC MISOPROSTOL 200MG TABLETS 60S

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INDICATIONS AND DOSAGE

NSAID-Induced Ulcer

Prophylaxis

200 mcg PO q6hr with food; may be decreased to 100 mcg q6hr if a higher dose is not tolerated; the last dose to be administered at bedtime

Should take therapy for the duration of therapy.

Stress Ulcer Prophylaxis (Off-label)

100-200 mcg PO q4-6hr

Induction of Labor (Off-label)

25 mcg intravaginally initially, then repeat at intervals not to exceed q3-6hr

Not to be used in patients with previous cesarean delivery or major uterine surgery

Postpartum Hemorrhage (Off-label)

Prophylaxis: 600 mcg PO within 1 minute of delivery

Treatment: 800 mcg PO once; use caution if prophylactic dose already given and adverse effects present or observed

Use only in settings where oxytocin not available

Treatment of Incomplete Abortion (Off-label)

600 mcg buccally once

Intrauterine Fetal Death (Orphan)

Treatment of intrauterine fetal death not accompanied by complete expulsion of products of conception in second and third trimesters of pregnancy

Dosing Modifications

Renal impairment: Use with caution; peak plasma concentration, half-life, and bioavailability may be increased, but it is not clear whether these increases are of clinical relevance

Adverse Effects